La ciencia que respalda lo que hacemos
La ciencia que respalda lo que hacemos
En cada uno de nuestros productos encontrarás más que una fórmula: encontrarás años de investigación, pruebas clínicas y evidencia validada por expertos. Aquí te compartimos los estudios que certifican su eficacia, calidad y seguridad.
2019. Artzi, O. Dual‐plane hyaluronic acid treatment for atrophic acne scars
2019. Tateo, A. Optimization of the lipofilling procedure with hybrid cooperative complexes of high and low molecular weight hyaluronic acid: preliminary experiments
2020. Cassuto, D. Treatment of Scar Contracture with Intralesional Jet-Assisted Injection of Hyaluronic acid
2020. Pavlova, N. Remodeling atrophic scar in the medial anterior region of the knee with hyaluronan hybrid cooperative complexes: a case report
2020. Siquier, G. Positive effect of hybrid stable cooperative complexes of high- and low-molecular-weight hyaluronic acid in psoriasis: a clinical series
2020. Siquier, G. Positive effect of hybrid stable cooperative complexes of high- and low-molecular-weight hyaluronic acid in psoriasis: a clinical series
2021. Rossi, E. Hybrid cooperative complexes of high- and low-molecular weight hyaluronic acid injections in a patient with a history of pulmonary sarcoidosis
2022. Akerman, L. A Combination of Non-ablative Laser and Hyaluronic Acid Injectable for Postacne Scars: A Novel Treatment Protocol
2022. Mohammed, G. Triple steps acne scar revision technique: A new combination therapeutic modality for atrophic acne scars
2022. Mohammed, G. Triple steps acne scar revision technique: A new combination therapeutic modality for atrophic acne scars
2023. Mehrabi, J. Comparison of 2 Hyaluronic Acid-based Fillers for the Treatment of Acne Scars: Structural Lifting Versus Biostimulatory Effect
2015. D’Agostino, A. In vitro analysis of the effects on wound healing of high- and low-molecular weight chains of hyaluronan and their hybrid H-HA/L-HA complexes
2016. Stellavato, A. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation
2017. Stellavato, A. Hybrid Complexes of High and Low Molecular Weight Hyaluronans Highly Enhance HASCs Differentiation: Implication for Facial Bioremodelling
2018. Alessio, N. Hybrid complexes of high and low molecular weight hyaluronan delay in vitro replicative senescence of mesenchymal stromal cells: a pilot study for future therapeutic application
2019. D’Agostino, A. In Vitro Evaluation of Novel Hybrid Cooperative Complexes in aWound Healing Model: A Step Toward Improved Bioreparation
2020. Stellavato, A. An in vitro study to assess the effect of hyaluronan-based gels on muscle-derived cells: Highlighting a new perspective in regenerative medicine
2021. La Noce, M. Hyaluronan-Based Gel Promotes Human Dental Pulp Stem Cells Bone Differentiation by Activating YAP/TAZ Pathway
2022. D’Agostino, A. Potential of Biofermentative Unsulfated Chondroitin and Hyaluronic Acid in Dermal Repair
2015. Laurino, C. Efficacy, Safety, and Tolerance of a New Injection Technique for High- and Low-Molecular-Weight Hyaluronic Acid Hybrid Complexes
2015. Rodríguez, M. Bio-remodelación facial mediante inyección intradérmica de un complejo híbrido estabilizado de ácido hialurónico de alto y bajo peso molecular: estudio prospectivo en 30 pacientes
2016. Beatini, B. Hyaluronic acid hybrid cooperative complexes and the BAP (Bio Aesthetic Points) technique: the new edge in biorejuvenation
2016. Sparavigna, A, Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation
2019. Goltzova, E. Hybrid cooperative complexes of H-HA and L-HA (Profhilo®) and the BAP technique for facial skin bioremodeling: a clinical experience at the NEO-Clinic (Tyumen, Russia)
2019. Paganelli, A. Synergic effect of plasma exeresis and non–cross‐linked low and high molecular weight hyaluronic acid to improve neck skin laxities
2019. Satardinova, E. Hybrid cooperative complexes of high and low molecular weight hyaluronans for facial skin rejuvenation in the Oriental mongoloid face: a case series
2020. Siquier, G. Neck rejuvenation with ha fillers, toxin and ha hybrid complexes
2021. Ribé, N. Amarna personal technique for rejuvenation of the neck area
2022. Sparavigna, A. Long Term Efficacy And Tolerance Of High-And Low-Molecular-Weight Hyaluronans (Profhilo®) intradermal injections
2022. Sparavigna, A, Efficacy and Tolerability of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan Intradermal Injections for the Treatment of Skin Roughness and Laxity of the Neck
2022. De Wit, A. A split-face comparative performance evaluation of injectable hyaluronic acid-based preparations HCC and CPM-HA20G in healthy females
2022. Noormohammadpour, P. Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
2023. Bezpalko, L. Clinical and Ultrasound Evaluation of Skin Quality After Subdermal Injection of Two Non-Crosslinked Hyaluronic Acid-Based Fillers
2023. Sparavigna, A. A pilot study testing efficacy and tolerability of hybrid cooperative complexes of hyaluronic acid intradermal injections in Chinese women
2023. Sparavigna, A. Neck and face rejuvenation outcomes with Profhilo®: a comparative analysis between Chinese and Caucasian cohorts
2024. Nakano, A. Development of a satisfaction survey to investigate pre- and post- treatment of the neck using hybrid cooperative complexes of hyaluronans in a cohort of Japanese patients
2025. de Castro Filho, A. Efficacy of Hybrid Cooperative Complexes of Hyaluronic Acid for Treating Hand Skin Laxity and Thickness: An Ultrasound-Based Evaluation
2025. Lam Bee Lan. Patient Satisfaction Using Hybrid Cooperative Complexes of Hyaluronic Acid for Neck Laxity: A Survey of Asian Populations
2017. Bovani, B. 7-point lift effect technique with hybrid cooperative complexes for the treatment of laxity associated with the inner arm
2022. Sparavigna, A. Hybrid cooperative complexes of high and low molecular weight hyaluronans (96 mg/3 mL) for the treatment of skin laxity of the inner arm and abdomen
2023. Casabona, G. Ex Vivo Product Distribution of Injectable Biostimulator Substances
2023. Sparavigna, A. Profhilo Body® for tackling skin roughness and laxity of inner arm, abdomen and knees.
2023. Sparavigna, A. Use of intradermic injection of hybrid cooperative complexes of hyaluronic acid to counteract Skin Roughness and Laxity on the Back of the Hands
2024. Margara, A. Body Skin Laxity Treatment Using Hybrid Cooperative Complexes of Hyaluronans: A Real-World Data Evaluation of Patient-Reported Satisfaction
2021. Cestone, E. Assessment of the efficacy of Profhilo® Figura Body Patch in reducing chemically induced skin redness and in improving skin moisturization
2016. Matic, I. Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence‐screening assay
2020. Cestone, E. Evaluation of the anti-ageing efficacy of Hilow Haenkenium cream in healthy woman
2020. Scrima, M. Evaluation of Wound Healing Activity of Salvia haenkei Hydroalcoholic Aerial Part Extract on in vitro and in vivo Experimental Models
2021. Cocetta, V. Further assessment of Salvia haenkei as an innovative strategy to counteract skin photo-aging and restore the barrier integrity